| Title: | Optimisation of the green process of industrial hemp - preparation and its extract characterisation |
|---|
| Authors: | ID Žitek Makoter, Taja (Author)
ID Kotnik, Petra (Author)
ID Makoter, Teo (Author)
ID Postružnik, Vesna (Author)
ID Knez, Željko (Author)
ID Knez Marevci, Maša (Author) |
|---|
| Files: |  plants-11-01749-v3.pdf (1,96 MB)
MD5: 2A266CB55E560962A56A3E6E178770A2
 https://www.mdpi.com/2223-7747/11/13/1749
|
|---|
| Language: | English |
|---|
| Work type: | Article |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: | FKKT - Faculty of Chemistry and Chemical Engineering
FS - Faculty of Mechanical Engineering
MF - Faculty of Medicine
|
|---|
| Abstract: | Natural medicines and products are becoming increasingly important in the pharmaceutical
and food industries. The most important step in obtaining a natural remedy is the processing of
the natural material. This study offers the separation of the industrial hemp plant into fractions by
mechanical treatment, which has a significant impact on the selectivity of the obtained fractions. This
study also offers a solution to reduce waste by fractionating industrial hemp, focusing on the fraction
with the highest cannabinoid content (49.5% of CBD). The study confirmed the anticancer potential
of the extract, which prevents further division of WM-266-4 melanoma cells at a concentration of
10−3 mg/mL. However, application of the extract (c = 10−3 mg/mL) to normal human epidermal
melanocytes proved to be insignificant, as the metabolic activity of the cells was the same as in the
control cell group. |
|---|
| Keywords: | supercritical fluid extraction, ultrasonic extraction, melanoma cells, extraction, WM-266-4 |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 15.06.2022 |
|---|
| Article acceptance date: | 28.06.2022 |
|---|
| Publication date: | 30.06.2022 |
|---|
| Publisher: | MDPI |
|---|
| Year of publishing: | 2022 |
|---|
| Number of pages: | 14 str. |
|---|
| Numbering: | Vol. 11, iss. 13 |
|---|
| PID: | 20.500.12556/DKUM-92747  |
|---|
| UDC: | 66.02 |
|---|
| ISSN on article: | 2223-7747 |
|---|
| COBISS.SI-ID: | 113614339 |
|---|
| DOI: | 10.3390/plants11131749 |
|---|
| Copyright: | © 2022 by the authors |
|---|
| Publication date in DKUM: | 09.05.2025 |
|---|
| Views: | 168 |
|---|
| Downloads: | 15 |
|---|
| Metadata: |    |
|---|
| Categories: | Misc.
|
|---|
|
:
|
Copy citation |
|---|
| | | | Average score: | (0 votes) |
|---|
| Your score: | Voting is allowed only for logged in users. |
|---|
| Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
