Upravljanje tekočinske bilance pri obsežnih opeklinah

Šadl, Manca

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Title:	Upravljanje tekočinske bilance pri obsežnih opeklinah
Authors:	ID Šadl, Manca (Author) ID Fekonja, Zvonka (Mentor) More about this mentor... ID Nemec, Gregor (Comentor)
Files:	MAG_Sadl_Manca_2025.pdf (768,61 KB) MD5: A0FDD5E0747EC97BB8F48613FE48E593
Language:	Slovenian
Work type:	Master's thesis/paper
Typology:	2.09 - Master's Thesis
Organization:	FZV - Faculty of Health Sciences
Abstract:	Uvod: Opekline so poškodbe tkiva, ki jih povzročajo različni dejavniki in pogosto vodijo v obsežno izgubo tekočin. Pri večjih opeklinah je ustrezno nadomeščanje tekočin ključno za preživetje, vendar ostaja optimalna strategija nejasna. Parklandska formula, ki je v klinični praksi najpogosteje uporabljena, je pogosto povezana s prekomernim nadomeščanjem tekočin in zapleti, kot so akutna ledvična odpoved, kompartment sindrom ali večorganska okvara. Namen zaključnega dela je raziskati in analizirati upravljanje tekočinske bilance pri pacientih z obsežnimi opeklinami. Metode: Izveden je bil pregled literature v podatkovnih bazah PubMed, Medline (EBSCOhost), CINAHL (Ultimate), Web of Science in ScienceDirect (Elsevier). Vključene so bile randomizirane kontrolirane raziskave v angleškem jeziku. Pregled literature je prikazan v PRISMA diagramu, kakovost raziskav pa je bila ocenjena s kritično analizo. Rezultati so prikazani v evalvacijski ter sintezni tabeli. Rezultati: V končno analizo so bile vključene 3 analize. Nobena od primerjalnih strategij, kot so uporaba formul za računanje (modificirana Brookova ali Baxterjeva formula), dodatek 5 % albumina ali uporaba HES 130/0,4, ni pokazala prednosti pred standardno kristaloidno terapijo. Kratkoročna 28-dnevna smrtnost je bila nizka in primerljiva med skupinami. Razprava in zaključek: Rezultati kažejo, da izbira formule ali dodatek koloidov ne izboljšata preživetja in ne zmanjšata zapletov pri odraslih z obsežnimi opeklinami, kadar je tekočinska terapija skrbno odmerjena. Ključnega pomena je natančno spremljanje diureze in vitalnih znakov.
Keywords:	upravljanje tekočinske bilance, nadomeščanje tekočin, opekline in izidi
Place of publishing:	Maribor
Publisher:	[M. Šadl]
Year of publishing:	2025
PID:	20.500.12556/DKUM-95468
UDC:	613.3:616-001(043.2)
COBISS.SI-ID:	256989187
Publication date in DKUM:	19.11.2025
Views:	191
Downloads:	28
Metadata:
Categories:	FZV
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Licences

License:	CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Link:	http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:	The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:	19.09.2025

Secondary language

Language:	English
Title:	Fluid management in extensive burns
Abstract:	Introduction: Burn injuries are tissue damages caused by various factors and are often associated with extensive fluid loss. In cases of major burns, appropriate fluid resuscitation is essential for survival; however, the optimal strategy remains uncertain. The Parkland formula, most commonly applied in clinical practice, is frequently associated with fluid overload and coplications such as acute kidney failure, compartment syndrome or multiple organ dysfunction. The purpose of this thesis is to investigate and analyze fluid management in patients with extensive burn injuries. Methods: A literature review was conducted using databases such Pubmed, Medline (EBSCOhost), CINAHL (Ultimate), Web of Science in ScienceDirect (Elsevier). Inclusion criteria included randomised controlled trials in English. The literature review was presented in a PRISMA diagram, while the quality of the included studies was evaluated through critical appraisal. The results are presented in the evaluation and synthesis tables. Results: Three analyses were included in the final synthesis. None of the comparative strategies such as the use of calculation formulas (Modified Brooke or Baxter formula), the addition of 5 % albumin, or the use of HES 130/0,4, demonstrated superiority over standard crystalloid therapy. The short term 28 – day mortality was low and comparable between groups. Discussion and conclusion: The findings indicate that neither the choice of formula nor the addition of colloids improves survival or reduces complications in adults with extensive burn injuries, provided that fluid therapy is carefully titrated. Precise monitoring od urine output and vital signs remains of paramount importance.
Keywords:	fluid management, fluid resuscitation, burns and outcomes

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