| Title: | Macromolecular inks of nanocellulose-alginate for direct-ink-writing : functional scaffolds enriched with curcumin extracts |
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| Authors: | ID Slaček, Gal (Author)
ID Mohan, Tamilselvan (Author)
ID Kotnik, Petra (Author)
ID Steindorfer, Tobias Alexander (Author)
ID Beaumont, Marco (Author)
ID Knez, Željko (Author)
ID Knez Marevci, Maša (Author)
ID Stana-Kleinschek, Karin (Author) |
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| Files: |  1-s2.0-S0141813025098186-main.pdf (7,77 MB)
MD5: 591C61E4AEAFB56ABCCD5A3FAF6EEA83
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | We present a scalable platform for the fabrication of multifunctional bioactive materials by integrating, polysaccharide-based matrices, green extraction and additive manufacturing. In this work, bioactive 3D-printed structures were fabricated using inks composed of nanofibrillated cellulose (NFC), alginate (Alg), and curcumin extracts. Bioactive compounds were efficiently recovered from turmeric via solvent-free supercritical carbon dioxide extraction, yielding up to 6.57 mg/100 g curcuminoids and 232.45 mg/100 g total phenols. The extracts exhibited robust antioxidant activity (DPPH• IC50: 23.24 mg/mL; ABTS+• IC50: 3.59 mg/mL) and broad-spectrum antimicrobial efficacy against Staphylococcus aureus, Escherichia coli, Candida albicans, and Pseudomonas aeruginosa (MIC: 9.38 mg/mL). Incorporation into NFC-Alg inks exhibited excellent shear-thinning properties suitable for direct-ink-writing 3D printing. Post-printing CaCl2 crosslinking further reinforced the hydrogel network, enhancing mechanical robustness and shape fidelity. The resulting constructs featured a highly porous, grid-like architecture with intricate surface morphology, highlighting significant potential for biomedical and tissue engineering applications. |
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| Keywords: | nanocellulose, alginate, curcumin extract, supercritical-CO2, antioxidant, antimicrobial properties, 3D-printing |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 07.08.2025 |
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| Article acceptance date: | 24.11.2025 |
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| Publication date: | 25.11.2025 |
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| Publisher: | Elsevier |
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| Year of publishing: | 2026 |
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| Number of pages: | 13 str. |
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| Numbering: | Vol. 335, Part 1, ǂ[article no.] ǂ149261 |
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| PID: | 20.500.12556/DKUM-96175  |
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| UDC: | 66 |
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| ISSN on article: | 1879-0003 |
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| COBISS.SI-ID: | 259537923 |
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| DOI: | 10.1016/j.ijbiomac.2025.149261 |
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| Copyright: | © 2025 The Authors
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| Publication date in DKUM: | 08.12.2025 |
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| Views: | 182 |
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| Downloads: | 14 |
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| Metadata: |    |
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| Categories: | Misc.
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