| Title: | A simplified longitudinal model for the development of Type 2 Diabetes Mellitus |
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| Authors: | ID De Gaetano, Andrea (Author)
ID Nagy, Ilona (Author)
ID Kiss, Daniel (Author)
ID Romanovski, Valery (Author) |
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| Files: |  1-s2.0-S0022519324001036-main.pdf (7,29 MB)
MD5: 97B4E6F1B9774EDAAC0FBD459F8B60A0
 https://www.sciencedirect.com/science/article/pii/S0022519324001036?via%3Dihub
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FERI - Faculty of Electrical Engineering and Computer Science
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| Abstract: | Obesity and diabetes are a progressively more and more deleterious hallmark of modern, well fed societies. In order to study the potential impact of strategies designed to obviate the pathological consequences of detrimental lifestyles, a model for the development of Type 2 diabetes geared towards large population simulations would be useful. The present work introduces such a model, representing in simplified fashion the interplay between average glycemia, average insulinemia and functional beta-cell mass, and incorporating the effects of excess food intake or, conversely, of physical activity levels. Qualitative properties of the model are formally established and simulations are shown as examples of its use. |
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| Keywords: | type 2 diabetes mellitus, mathematical model, glucose, insulin, beta-cell mass |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 25.10.2023 |
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| Article acceptance date: | 27.03.2024 |
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| Publication date: | 07.04.2024 |
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| Publisher: | Elsevier |
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| Year of publishing: | 2024 |
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| Number of pages: | 17 str. |
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| Numbering: | Vol. 587, [article no.] 111822 |
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| PID: | 20.500.12556/DKUM-96766  |
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| UDC: | 616.378 |
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| ISSN on article: | 0022-5193 |
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| COBISS.SI-ID: | 195458307 |
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| DOI: | 10.1016/j.jtbi.2024.111822 |
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| Copyright: | © 2024 The Authors |
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| Publication date in DKUM: | 28.01.2026 |
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| Views: | 175 |
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| Downloads: | 1 |
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| Metadata: |    |
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| Categories: | Misc.
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