| Title: | Potential health benefits of probiotic strains of Clostridium butyricum |
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| Authors: | ID Šikić Pogačar, Maja (Author)
ID Pogačar, Mia (Author)
ID Fijan, Sabina (Author) |
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| Files: |  2026-applmicrobiol-Cl_butyricum.pdf (427,39 KB)
MD5: A52929AFF35D111DFB85EFB22B249273
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| Language: | English |
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| Work type: | Unknown |
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| Typology: | 1.02 - Review Article |
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| Organization: | FZV - Faculty of Health Sciences
MF - Faculty of Medicine
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| Abstract: | Clostridium butyricum is a well-known Gram-positive, spore-forming, obligate anaerobic, and butyrate-producing bacterium with a few species of next-generation probiotic strains. By far, the most well-known strain is Clostridium butyricum CBM588 (also known as MIYAIRI 588). This strain has gained significant attention for its therapeutic potential across a variety of human health conditions. Preclinical studies have shown its ability to stabilize gut microbiota, enhance short-chain fatty acid (SCFA) production, and modulate immune responses, which contribute to its therapeutic effects in conditions such as ulcerative colitis, allergies, and cancer. We examined 28 interventional clinical trials and 7 observational studies investigating the effect of Clostridium butyricum strains. These studies have supported the findings of preclinical trials and demonstrated symptom improvement and immune modulation in diverse conditions. Clostridium butyricum CBM588 has shown efficacy in managing gastrointestinal diseases, such as acute gastroenteritis and inflammatory bowel disease, and has also proven beneficial in immune modulation, as evidenced by its positive effects in allergic rhinitis and cancer immunotherapy. Additionally, CBM588 has been reported to have a favorable safety and tolerability profile in various patient populations, including children, adults, and critically ill patients. Despite these promising results, clinical studies face limitations such as small sample sizes, varied protocols, and short study durations. Future well-designed, large-scale trials are necessary to further validate the long-term safety and efficacy of Clostridium butyricum in clinical practice. |
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| Keywords: | Clostridium butyricum, spore-forming bacteria, probiotics, health benefits |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 01.04.2026 |
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| Article acceptance date: | 04.04.2026 |
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| Publication date: | 08.04.2026 |
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| Publisher: | MDPI |
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| Year of publishing: | 2026 |
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| Number of pages: | 31 str. |
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| Numbering: | Letn. 6, št. 4, št. članka 53 |
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| PID: | 20.500.12556/DKUM-97771  |
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| UDC: | 613:613.292:579.852 |
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| ISSN on article: | 2673-8007 |
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| COBISS.SI-ID: | 274733059 |
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| DOI: | 10.3390/applmicrobiol6040053 |
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| Publication date in DKUM: | 13.04.2026 |
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| Views: | 263 |
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| Downloads: | 12 |
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| Metadata: |    |
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| Categories: | Misc.
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