| Title: | Stability of ranked gene lists in large microarray analysis studies |
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| Authors: | ID Štiglic, Gregor (Author)
ID Kokol, Peter (Author) |
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| Files: |  Journal_of_Biomedicine_and_Biotechnology_2010_Stiglic,_Kokol_Stability_of_Ranked_Gene_Lists_in_Large_Microarray_Analysis_Studies.pdf (1,39 MB)
MD5: 8E8DA45D7193174D520C763A79CAE698
PID: 20.500.12556/dkum/d3101b42-c9de-4202-9762-a4ef279fb518
 http://www.hindawi.com/journals/bmri/2010/616358/
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FZV - Faculty of Health Sciences
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| Abstract: | This paper presents an empirical study that aims to explain the relationship between the number of samples and stability of different gene selection techniques for microarray datasets. Unlike other similar studies where number of genes in a ranked gene list is variable, this study uses an alternative approach where stability is observed at different number of samples that are used for gene selection. Three different metrics of stability, including a novel metric in bioinformatics, were used to estimate the stability of the ranked gene lists. Results of this study demonstrate that the univariate selection methods produce significantly more stable ranked gene lists than themultivariate selection methods used in this study. More specifically, thousands of samples are needed for these multivariate selection methods to achieve the same level of stability any given univariate selection method can achieve with only hundreds. |
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| Keywords: | gene selection techniques, microarray, analysis studies |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2010 |
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| Number of pages: | str. 1-9 |
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| Numbering: | Letn. 2010 |
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| PID: | 20.500.12556/DKUM-30841  |
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| ISSN: | 1110-7243 |
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| UDC: | 004.8:575 |
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| ISSN on article: | 1110-7243 |
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| COBISS.SI-ID: | 1615268 |
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| DOI: | 10.1155/2010/616358 |
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| NUK URN: | URN:SI:UM:DK:EJDX3NDN |
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| Publication date in DKUM: | 05.06.2012 |
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| Views: | 2236 |
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| Downloads: | 404 |
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| Metadata: |    |
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| Categories: | Misc.
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