| Title: | Prediction of suicide attempts in depressive disorder and panic disorder with/without agoraphobia : multivariate analysis of clinical predictors |
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| Authors: | ID Batinić, Borjanka (Author)
ID Kecman, Barbara (Author)
ID Opačić, Goran (Author)
ID Štuhec, Matej (Author) |
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| Files: |  RAZ_Batinic_Borjanka_2026.pdf (499,66 KB)
MD5: BA03D98095887D5DC445AE51E9AF5822
 https://doi.org/10.3389/fpsyt.2026.1710182
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1710182/full
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Introduction: Suicide risk in patients with depressive disorder (DD) and panic disorder with or without agoraphobia (PD/A) is often associated with depression, hopelessness, and anxiety-related factors, but their predictive roles remain unclear.Aim: To identify the strongest clinical predictors of suicide attempts in patients with DD and PD/A, and to assess the applicability of a predictive model within and across diagnostic groups.Methods: A total of 94 patients (48 with DD- acute or recurrent, 46 with PD/A) were assessed using the Beck Scale for Suicide Ideation (BSSI), Beck Depression Inventory-II (BDI-II), Beck Hopelessness Scale (BHS), Anxiety Sensitivity Index-Revised (ASI-R), and Beck Anxiety Inventory (BAI). Univariate and multivariate analyses were conducted to evaluate the relative predictive value of these factors for suicide attempts within and across diagnostic groups.Results: Suicide attempts were reported by 23 patients with DD (48%) and only one patient with PD/A (2.17%). In DD sample, suicidal ideation was the strongest predictor of suicide attempts, followed by depression severity. ROC analyses indicated optimal cut-offs of 11 for BSSI and 35 for BDI-II, yielding high sensitivity (82.6%) and specificity (92%). Hopelessness and anxiety sensitivity did not retain predictive value in multivariate analysis, whereas panic/agoraphobic symptoms showed a suppressor effect, reducing risk by 11%. When applied to the PD/A group, the model estimated an average predicted risk of 9.3%, but failed to identify the single attempter, resulting in zero sensitivity.Conclusions: High levels of suicidal ideation and depressive symptoms were the strongest predictors of suicide attempts in DD. Panic and agoraphobic symptoms exerted a suppressor effect on suicide risk. In the PD/A group, however, the model’s predictive utility was extremely limited due to the very low number of suicide attempts, and these findings should therefore be considered preliminary. |
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| Keywords: | depressive disorder, multivariate analysis, panic disorder/agoraphobia, prediction, suicide attempts |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 05.01.2026 |
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| Article acceptance date: | 27.01.2026 |
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| Publication date: | 17.02.2026 |
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| Publisher: | Frontiers |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-8 |
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| Numbering: | Letn. 17, Febr. 2026, št. članka 1710182 |
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| PID: | 20.500.12556/DKUM-97971  |
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| UDC: | 616.89 |
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| ISSN on article: | 1664-0640 |
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| COBISS.SI-ID: | 276164611 |
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| DOI: | /10.3389/fpsyt.2026.1710182 |
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| Publication date in DKUM: | 05.05.2026 |
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| Views: | 151 |
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| Downloads: | 4 |
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| Metadata: |    |
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| Categories: | Misc.
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